1-N-Boc-3-Methylpiperidine-3-carboxylic acid - Names and Identifiers
Name | 1-N-Boc-3-Methylpiperidine-3-carboxylic acid
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Synonyms | 1-BOC-3-METHYLPIPECOLINIC ACID 1-Boc-3-Methyl-3-piperidinecarboxylic acid 1-N-Boc-3-Methylpiperidine-3-carboxylic acid 1-N-Boc-3-Methyl-Piperidine-3-Carboxylic Acid 1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid 3-Methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester 3-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester 1,3-Piperidinedicarboxylic acid, 3-methyl-, 1-(1,1-dimethylethyl) ester
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CAS | 534602-47-6
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InChI | InChI=1/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-6-12(4,8-13)9(14)15/h5-8H2,1-4H3,(H,14,15) |
1-N-Boc-3-Methylpiperidine-3-carboxylic acid - Physico-chemical Properties
Molecular Formula | C12H21NO4
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Molar Mass | 243.3 |
Density | 1.129 |
Boling Point | 354.3±35.0 °C(Predicted) |
Flash Point | 168.1°C |
Vapor Presure | 5.65E-06mmHg at 25°C |
pKa | 4.53±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.489 |
1-N-Boc-3-Methylpiperidine-3-carboxylic acid - Introduction
Acid is an organic compound whose structure contains a N-tert-butoxycarbazyl (Boc) protecting group, a methyl group and a piperidine ring. The following is a description of its nature, use, preparation and safety information:
Properties: acid is a white or off-white solid. It is stable at room temperature, but sensitive to light. It is soluble in common organic solvents such as chloroform, dichloromethane, ethanol and methanol, and slightly soluble in ether solvents.
use: acid is commonly used in drug synthesis and organic synthesis. As an organic synthesis intermediate, it can be used to synthesize a variety of biologically active compounds, such as drugs, pesticides and dyes.
preparation method: acid can be prepared by the following steps:
1.3-methyl -3-piperidinecarboxaldehyde and tert-butyl tert-propyl ammonium oxide (TBAOH) are reacted to generate the corresponding enol aldehyde compound.
2. The enol aldehyde is reacted with di-tert-butyldiborane (B2(pin)2) to obtain the corresponding alcohol compound.
3. React with N-tert-butyloxycarbazol (Boc2O) under alkaline conditions to generate the target product acid.
Safety information: acid is safer under normal operating conditions, but the following matters still need to be paid attention:
1. Wear appropriate protective gloves, goggles and protective mask to avoid contact with skin, eyes or inhalation of dust.
2. Avoid operating near the fire source to prevent its ignition.
3. Storage should be sealed, and placed in a cool, dry place, away from fire and strong acid and alkali.
4. in case of accidental contact or accidental administration of the substance, please seek medical treatment in time and bring the original packaging for processing.
The above content is for reference only. When using and handling the compound, please follow the relevant laboratory and safe operation specifications.
Last Update:2024-04-09 18:58:34